A dozen years ago the biggest risk of a startup smacked me upside the head: the company ran out of money and closed it's doors. Since that first experience in the high-tech* startup world, I've worked at a half-dozen or so other such companies. Over half of them are no longer in existence.
I have accepted that, but I was never happy with it. This past summer things went downhill with my latest company. Within a month I had offers from three companies: a temporary contract gig at a mid-sized company, a large fortune 500 type, and another startup. Sometimes it is good to mix it up, so I decided to ride with the behemoth. I've been here two months now - we'll see how it goes.
* My definition of a "high-tech" startup includes actual hardware. I'm sure a lot of smart people work at companies developing new apps for smartphones, algorithms for web-hosted databases, or some other clever software tool. But unless it involves some newly-discovered applications of physics/chemistry/biology, it doesn't meet my criteria. That's just my bias.